A few follow-ups

Follow-up comments on some things I've written about lately.

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Long-time readers may remember a brief discussion in a Comments section concerning my (ahem) admiration for Barry Manilow. I'm not alone. Apparently, basketball star LeBron James is also a fan. His Olympics teammate Carmelo Anthoy, too, is a fan of The Man (as we call him).

Bron-Bron has only a few Manilow songs on his iPod, but one of them is Copacabana, and if you're going to have just one of his songs on your iPod, I'd say that's the one to have. But I'm open to other suggestions.

Try Googling "LeBron Manilow," and you'll see just how many news outlets have links to this story. I have no idea why this is news. Post-election boredom, I guess.

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I mentioned in June that I went to a Phillies game this summer, and they went on to win the World Series. (That's two years in a row that a team I saw won the series that year. If any other teams' fans want to pay for a trip next summer, I'll listen.) The first baseball team I ever played on -- sponsored by a dentist -- was known as the Doc Gallagher Phillies, so I have a soft spot in my heart for them. Mike Schmidt, Greg Luziniski, Steve Carlton, Bob Boone, Larry Bowa -- my favorite non-Red Sox players when I was a kid were on the Phillies.

They had a World Series victory parade a few weeks ago, of course, so this link harkens back to my drunk-Phillies-fan-with-plumber's-crack link and my laughing baby link from a few weks ago. It's a short video of a toddler (he can't be more than about 15 months old) at the Phillies parade. While they were waiitng for the Phillies, the fans entertained themselves by watching him and cheering him on whenever he raised his arms. It's very darn cute. The video description says that people were cheering for him as far up and down the street as they could see.

Reminds me of those "I'm the center of the universe" days that my kids are (mostly) done with now.

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An update on my annual physical (the one from the General Practitioner, not one of my visits to Dr. R). My blood test results are back.

My total cholesterol is 179; below 200 is the goal. My HDL (good cholesterol) is 47; above 40 is the goal. My LDL (bad cholesterol) is 120; below 130 is the goal. My Triglycerides are 61; below 150 is the goal.

Blood chemistries and blood count are normal (these are the things that Dr. R checks too, so I assume my visit with him in a few weeks will be fine). No problems with thyroid or PSA.

So, once again, proof that I'm the healthiest gosh darn cancer patient around.

One thing I though was pretty intersting, though: my cholesterol numbers are very close to last year's. This year, When the doctor mailed me the results, he written comment on the form was "Good." Last year, she wrote "Perfect!" Similar numbers, so why less enthusiasm? Probably doesn't want me to get too cocky, with the cancer thing and all, but I don't think it's fair that I lose points that way. I'd be mad if I didn't think it was amusing.

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Finally: a happy birthday to my brother. How does it feel to be 50?

(I know you're not 50 yet, but I figured you'd probably know how it feels.)

Too Bad.....

Well, for every clinical trial for a wonder drug like Rituxin or an improvement like Zevalin, there are probably 100 attempts at something else to treat or cure cancer that don't work out. I came across another one this week, and it really bummed me out that it probably isn't going to work.



A guy named Dr. Bill Cham has a new book out called The Eggplant Cancer Cure; his website is EggplantCancerCure.com. According to the web site, "Dr. Cham has found substances which can penetrate and kill skin cancer cells but can’t penetrate normal skin cells, so normal skin cells are untouched and unhurt while the skin cancer cells die!" He claims to have conducted extensive studies on a cream he made (called Curaderm), which contains substances derived from eggplant. The cream is rubbed on skin cancer tumors (including late stage melanoma), and in a period of months, reduces the tumors and cures the cancer. He claims it has cured 70,000 skin cancer patients in Australia, and he's working on a way to make it work on internal tunors as well.



By the way, he isn't an M.D, he has a "Ph.D. in Medicine." And we all know how useful a Ph.D. is....



It all sounds great, but there are some problems. He claims that the cream has been through Stage I, Stage II, stage III, and Stage IV clinical trials, but apparently, there isn't any published record of them. His website lists a bunch of publications supporting Curaderm, but some have titles like The Skin Cancer Cure So Effective, It's Being Kept Secret. There's a nice critique of Cham and Curaderm from a blog called Respectful Insolence, which looks at a lot of cancer cure claims like this.

I'm a little skeptical of any cancer cure that's being kept a secret.

There are two important lessons to be drawn from all of this:

1) There are a ton of cancer cure claims online. I know someone who's pushing some kind of juice on me that costs $40 a quart. But there's no real evidence that it actually wortks, apart from some personal testimonials. I can't afford $40 juice, and I can't emotionally afford "cures" that may or may not work. I have no problem with alternative medicine and natural cures, and I avoid drugs of all kinds unless I absolutely need them. An apple a day really does help keep the doctor away. I'm an antioxidant freak. But part of the problem with follicular NHL, in terms of alternative and natural cures, is that it's so slow growing, and it waxes and wanes, that it's nearly impossible to isolate something and say it's the cause of the improvement. Very frustrating. But I still eat a lot of fruit anyway.

2) I really wish eggplant was a cure for cancer. As my brother can attest, our Mom makes the best eggplant parm in the world. It's come up on the blog more than once. In fact, if eggplant provided a topical treatment for skin cancer, my brother and I would rub eggplant parm all over ourselves. And frankly, it wouldn't be the first time someone has done it.

The author of the Respectful Insolence blog does not completely discount the idea that compounds in eggplant can help skin cancers, he just wishes Dr. Cham would submit the treatment to more rigorous testing than Cham has been willing to do. As you know from reading the blog, I'm very willing to be part of a clinical trial. So I hearby volunteer to consume my mother's eggplant parm every chance I get, in the hopes that it can help provide data for researchers working for a cure.

Just doin' my part.

My Buddy Z

....By which I mean Zevalin, the RIT (RadioImmunoTherapy) treatment that I've written about several times before. More good news about its effectiveness.


To review: "Liquid" cancers like NHL are hard to treat with radiation because the cancer cells don't hold still -- there's nothing to aim the radiation at. The development of Rituxin, an antibody that recognizes B cells (including the cancerous ones) and attaches to them, was a huge advance for lots of reasons (and even more reasons are popping up). Zevalin (and its cousin Bexxar) are basically radioactive Rituxin -- Zevalin attaches itself to the B cells and delivers a dose of radiation to them. It's a pain to administer (you need to assemble a team of nurses, radiologists, and nuclear medicine specialists to do it), but in theory, it's a great therapy, combining a couple of different types of treatment. But studies are trickling in to show that it's meeting that great theoretical promise.


The October issue of the Journal of Clinical Oncology includes an editorial from Oliver W. Press, a researcher from the Fred Hutchinson Cancer Research Center and University of Washington in Seattle. (He's a big name from a big research center).


In a nutshell, Press reviews a couple of recent clinical studies of Zevalin, and while he points out some problems with the ways the studies were conducted, he's very hopeful about the results, and thinks they signal a huge advance in treating indolent lymphomas like Follicular NHL.


As Press points out, Zevalin has been used up top this point as a "down the line" treatment -- when chemo stops working, you turn to RIT. It's been fairly successful when used this way.


However, a major new study looked at Zevalin as a first-line treatment. In other words, the study looked at people who were given Zevalin before they received any chemo or other treatments. The results were impressive: patients given either Zevalin by itself, or Zevalin combined with chemo, showed 90-100% response to the therapy, with up to 90% showing complete response (the lymphoma was wiped out, at least temporarily).

A second study that Press describes looked at using higher-than-normal doses of Zevalin after a shortened course of chemo (three doses instead of the usual six), and also came with encouraging results. The chemo wiped out a lot of the cancer cells, and the Zevalin took care of the rest. Combining the treatments means attacking in different ways, and increasing the chances that you'll hit more of the cancer.

This morning, I read about a third, similar study that looked at a patients with advanced follicular NHL (they were in the "bulky" stage, meaning their nodes were more than 10 centimeters, or about three inches), who were given a shortened course of chemo, followed by Zevalin, then followed by Rituxin. Similarly good results -- nearly 90% of patients were still in remission after two years. The study is ongoing.

It's all very encouraging, not just for the results themselves, but because they should inspire more people to try Zevalin (or Bexxar) and encourage researchers to keep tinkering with dosages, sequences, and follow-ups. I'm convinced RadioImmunoTherapy is going to play a bigger role in treatments soon, and we (the NHL community) are all going to be happy we gave it a chance.

A Few Pictures

You know you haven't posted any pictures in a while when you go to post some, and realize you've forgotten how to do it....

Now that I've figured it out, here are a few pictures.

Halloween.

Peter dressed as a biker. He went to his middle school Halloween dance, and was a finalist for Best Homemade Costume, probably because it's a complete 180 from what his teachers know of him.

Catherine was Hannah Montana, which is no surprise, because the Connecticut governor issued an Executive Order this year that every girl in the state between 5 and 8 had to dress as Hannah Montana. (By the way, Catherine still has superstar amibitions, and still plans to call herself Morgan Oregan when it happens.)

John went as a Jedi Master. The tunic is store-bought, but Isabel made the brown Jedi robe, to John's specifications (that it be easy to throw off, should a light saber battle break out. Which has happened more than once since she finished the robe).

I think Peter is worth looking at one more time.

By the way -- I chaperoned the middle school dance. I went as Joe the Plumber. (Nobody got it, despite the name tage that says "Hello, my name is Joe." "Are you Bob the Builder?" No, I'm not. Go read a newspaper.)

Finally: Strudel dressed for Halloween, too. She was a medieval princess.

I love this picture. She was about as miserable as she looks....

Doldrums

I've had a few things I've wanted to write about -- praising old poeple for their athletic accomplishments; posting some new pictures; giving some very exciting updates about Zevalin, the RadioImmunoTherapy treatment. But I can't work up the energy.

Which isn't to say I'm feeling fatigue (one of those "B symptoms" I'm supposed to watch out for). I'm feeling just fine, physically. I think we're getting to that point in the semester when everyone is just spent. Midterms are over, Thanskgiving break is a few long weeks away, and everyone is just kind of feeling mentally fatigued. Unfortunately, students feeling this way drag teachers down with them.

I have an afternoon full of meetings, including one where the university President and the Finance VP will tell us how bad the school's budget is right now. That will be an uplifter, I'm sure.

The good news is, I'm still the healthiest darn cancer patient around (go for my cholesterol etc. blood test tomorrow morning), I have a job that I like, and I'm not the chair any more, so I'm not the one that has to worry about the budget.

I'll feel beeter next week, I'm sure.

Happy Election Day

I try to stay out of politics with the blog, and today is no exception. Just two links, with comments:

First, I thought John McCain's Saturday Night Live/QVC performance was wonderful. He's very good at laughing at himself (and SNL was very good about giving him some good lines). Can't get the link from NBC to work, but check it out yourself (here's the lkink to the main NBC page).

Here's a link that will work. It's called "John McCain gets BarackRoll'd." It's a take on an internet prank called "RickRolling": someone sets up a link that promises something good (like a scandelous photo of a celebrity), but when the link is clicked, you get a video of the song Never Gonna Give You Up" by Rick Astley. (Here's the original.) This prank is itself a take on a similar prank, but the link took you to a photo of a toy duck on wheels (so you'd be "duck rolle'd"). Very clever editing. I like it when people take time to do their satire right.

Most of all, I like seeing Obama dancing. I'd love to find a video of McCain dancing, but they're all fakes. Having both candidates dance would justify one my favorite quotes, from James Brown, my icon and my avatar:

"The one thing that can solve most of our problems is dancing."

Now go vote.

A First -- A Third!

Yesterday was a running milestone for me. I came in third in my age group in a race, and won a prize, for the first time ever.

The race was the Bob Corda Memorial 5K, which is part of Homecoming Weekend at Southern. I've run in it twice before. It's usually a pretty small field of faculty, staff, students, and alumni. This year, with it starting at 8:00am on the morning after Halloween, and with the temperature a chilly 43 degrees at the start, there were almost no students running. But there seemed to be about the same number of "Masters Runners," as we over-40 folks are called.


I know a lot of the people who run in this race, and I use that as inspiration. Last year, I finished just behind a certain faculty member from the Computer Science department, and I really wanted to beat him this year. I started the race kind of easy, and about a mile into it, I found myself next to this guy. I stayed with him for a couple of minutes, and then turned it up just a little bit and pulled ahead of him.

Next on my radar was the race organizer, a staff member who works closely with Student Government. Since students were helping with the race, telling us where to turn on the course, they all cheered for her whenever they saw her. Since I was just behind her for a while, I thought they were cheering for me, until they said her name. But I took that as some inspiration and passed her, too.

At about 2 miles, I was passed by a man about my age. I kept him in my sight, hoping I'd be able to pass him near the end, if I kept something in reserve. Passing him was important -- I wasn't sure if he was in my age group, but I thought he might be, and since I placed 4th last year, I figured if I could pass one person, I'd have a shot at a prize this year. With about a half mile left, slowed down, rubbing his calf. I asked him if he was OK as I passed him. (He said he was fine.)


(A cheap victory, coming in third because of an injury to an opponent? Heck no. The race isn't just about what happens on the course that day. It's about everything you do leading up to that point, too. My superior training and preparation paid off for me. I earned it.)


I finished in 28:38 (about 9:14 per mile), one second slower than the race I ran in Massachusetts in late September. I was hoping for a little faster time, but I'll take it. It earned me third place in the Male 40-49 year old division, and my prize was a $5.00 gift card to Dunkin Donuts. After the race, I used it to buy coffees for Isabel and me, and then I met her at John's soccer game.


(But the DD people let me keep the card. I'm going to frame it.)


The official Homecoming photographer was at the race, so I'll have a link in a few days with a picture or two of me on the Southern website.