Many thanks to Ann Erikson, who let me know that the good folks at Patient Power just posted a video discussing Idelalisib/Zydelig, and what the FDA approval means for patients with relapsed Follicular Lymphoma. I hadn't visited Patient Power in a while, so I'm glad someone else was on top of it. Ann found the video "very encouraging," and I would have to agree.
And it sounds like Dr. John Pagel, from Fred Hutchinson Cancer Center in Seattle, is also very encouraged. He is interviewed in the video by Andrew Schorr, who founded Patient Power (and who does so much to educate the cancer community).
Dr. Pagel describes Idelalisib/Zydelig as "patient friendly," fairly well-tolerated, and allowing for a relatively normal life.He calls it a "revolutionary approach."
He also is excited above the FDA's Accelerated Approval for the treatment (something I also thought was pretty significant).
Finally, and while I'm reluctant to say it, Dr. Pagel thinks a cure is not far off. "It's a great time to be a researcher," he says, and not the worst time to be a Follicular Lymphoma patient.
Thanks again, Ann.
Thursday, July 31, 2014
Monday, July 28, 2014
Follicular Lymphoma's Improving Survival Rate (in Europe)
Still easing my way back from two weeks in the U.K, so let's talk about Europe....
The Lancet Oncology published an article a couple of weeks ago that looks at improving survival rates in Europe. Good news -- Follicular Lymphoma survival rates are improving.
The study looked at data from 30 cancer registries from 20 countries in Europe. Using that sample, they did some statistical analysis, and found that most blood cancers had improved survival rates from 1997 to 2007. For Follicular Lymphoma, the 5 year survival rate for 1997-1999 was 58.9%; that went up ten years later to 74.3%, the second best improvement for the diseases being measured (behind only DLBCL). They found that Eastern Europe lagged behind the rest of the continent, but all other regions of Europe improved.
Their Interpretation reads as follows: "These trends are encouraging. Widespread use of new and more effective treatment probably explains much of the increased survival. However, the persistent differences in survival across Europe suggest variations in the quality of care and availability of the new treatments. High-resolution studies that collect data about stage at diagnosis and treatments for representative samples of cases could provide further evidence of treatment effectiveness and explain geographic variations in survival."
So, clearly, improved treatments account for the great bulk of improved survival. It's no coincidence that they measured at the start of the Rituxan Era, and more targeted treatments continue to be introduced. It's certainly possible that the same cohort, if measured in 2017, would come out even better.
Of course, this is a measure of European blood cancer patients, so it isn't necessarily comparable to the United States (where I have an obvious interest), but my guess is that survival rates have made similar improvements in the U.S. over that time. (I know statistics like that are out there, and I've probably written about them at some point, but I'm too lazy to look them up right now.)
I see two big lessons in this study.
The first has to do with the authors' comment on Eastern Europe. They say that treatments like Rituxan and Velcade are approved across Europe, but access is less common in Eastern Europe. This might explain the lower survival statistics. I think there's a lesson there for the U.S. -- better access to treatments might be more common for lots of people who couldn't afford them until a few years ago, when health insurance reform allowed for better access. It would be interesting to see survival statistics in a few years with that factor in mind: will survival numbers increase not only because we have better treatments, but because more people can actually use them?
The second lesson is related to the first: Statistics don't tell the whole story.
We know that, of course, but we sometimes forget that statistics are made up of individuals, and not all individuals are alike. So we can look at a statistic about survival, and assume that everyone in some sample of 1000 Follicular Lymphoma patients is just like us. But, of course, they aren't. They are of different ages, they live different lives, they have different genetic make-ups -- and they have different access to treatments. A 70 year old Polish woman does not equal a 40 year old Italian man. Not everyone is going to be just like me. (Very few will be as handsome, for example....)
It's yet another reason to look at statistics with a critical eye. We often look to statistics to make ourselves feel better, and sometimes that doesn't work, and the numbers we read just make us feel horrible. And if that happens, remind yourself that a group of random strangers doesn't say anything about who you are and what you need.
Then go have some ice cream.
The Lancet Oncology published an article a couple of weeks ago that looks at improving survival rates in Europe. Good news -- Follicular Lymphoma survival rates are improving.
The study looked at data from 30 cancer registries from 20 countries in Europe. Using that sample, they did some statistical analysis, and found that most blood cancers had improved survival rates from 1997 to 2007. For Follicular Lymphoma, the 5 year survival rate for 1997-1999 was 58.9%; that went up ten years later to 74.3%, the second best improvement for the diseases being measured (behind only DLBCL). They found that Eastern Europe lagged behind the rest of the continent, but all other regions of Europe improved.
Their Interpretation reads as follows: "These trends are encouraging. Widespread use of new and more effective treatment probably explains much of the increased survival. However, the persistent differences in survival across Europe suggest variations in the quality of care and availability of the new treatments. High-resolution studies that collect data about stage at diagnosis and treatments for representative samples of cases could provide further evidence of treatment effectiveness and explain geographic variations in survival."
So, clearly, improved treatments account for the great bulk of improved survival. It's no coincidence that they measured at the start of the Rituxan Era, and more targeted treatments continue to be introduced. It's certainly possible that the same cohort, if measured in 2017, would come out even better.
Of course, this is a measure of European blood cancer patients, so it isn't necessarily comparable to the United States (where I have an obvious interest), but my guess is that survival rates have made similar improvements in the U.S. over that time. (I know statistics like that are out there, and I've probably written about them at some point, but I'm too lazy to look them up right now.)
I see two big lessons in this study.
The first has to do with the authors' comment on Eastern Europe. They say that treatments like Rituxan and Velcade are approved across Europe, but access is less common in Eastern Europe. This might explain the lower survival statistics. I think there's a lesson there for the U.S. -- better access to treatments might be more common for lots of people who couldn't afford them until a few years ago, when health insurance reform allowed for better access. It would be interesting to see survival statistics in a few years with that factor in mind: will survival numbers increase not only because we have better treatments, but because more people can actually use them?
The second lesson is related to the first: Statistics don't tell the whole story.
We know that, of course, but we sometimes forget that statistics are made up of individuals, and not all individuals are alike. So we can look at a statistic about survival, and assume that everyone in some sample of 1000 Follicular Lymphoma patients is just like us. But, of course, they aren't. They are of different ages, they live different lives, they have different genetic make-ups -- and they have different access to treatments. A 70 year old Polish woman does not equal a 40 year old Italian man. Not everyone is going to be just like me. (Very few will be as handsome, for example....)
It's yet another reason to look at statistics with a critical eye. We often look to statistics to make ourselves feel better, and sometimes that doesn't work, and the numbers we read just make us feel horrible. And if that happens, remind yourself that a group of random strangers doesn't say anything about who you are and what you need.
Then go have some ice cream.
Saturday, July 26, 2014
I'm Back!
My two vacation is over. I got back just in time to hear the news about the FDA approving Idelalisib/Zydelig for Follicular Lymphoma, and to post something quick on Thursday morning, but it's mostly been recovery and catching up for a couple of days since then.
My wife, kids, and I went to the United Kingdom for two weeks -- 5 days in London, 4 in Cornwall in Southwest England, and then 5 days up north in Edinburgh, Scotland. It was a great trip for all of us. My Doctor Who fan daughter got to see the TARDIS in Earls Court; my middle child, who has embraced his Scottish heritage, got to eat real haggis in Scotland; and my oldest, the jazz musician, got to see Bill Evans and Mike Stern, who played with Miles Davis in the 80's, in concert as part of the Edinburgh Jazz and Blues Festival.
It was the first visit to England for me and the kids, though my wife had been there before we were married. So this was also her way of keeping her promise to show me England some day. I still need to keep my promise to show her Italy, where I lived for 10 months years ago.
It was a great trip, and a much-needed one. We had a really tough spring. My shoulder surgery and recovery was only a part of it, and I won't get into the rest of it here. But it seemed like someone was just piling more and more tests on us as the spring went on. We passed those tests, and we're all better for it. And the trip to England and Scotland became, in some ways, a celebration of getting through the spring, a way of re-setting our lives and starting over, but also a way of remembering someone we love.
And while it seemed like I had been writing from the UK every few days, to be honest, I had actually written most of that stuff before I left, and posted it as I went along. That meant that I took a chance on writing a post about missing our dog, but it worked out OK, because we really did miss her. And she missed us, too. She didn't pass out when she saw us, like this other schnauzer did (in a video conveniently posted on YouTube yesterday), but she was happy to see us anyway.
It's funny, though, how it's almost impossible to take a vacation from cancer. It seemed like there was always a reminder. One museum we visited showed artifacts from vikings who had lived on the British Isles, including a quiver full of arrows -- anyone who has read this blog knows the specialist I saw long ago called the available lymphoma treatments the "arrows in your quiver." And it seemed like every major street in every town we visited had a few "charity shops," what we in the U.S. know as Goodwill or Salvation Army stores. And a whole bunch of those shops supported Cancer Research UK. And then outside Edinburgh Castle, a man dressed as William Wallace from Braveheart (as opposed to the real William Wallace) posed for pictures with tourists, accepting donations in a box, with a sign that said "All Donations to Support Leukemia Research."
I think we all probably knew already that there's no vacation from cancer. And that's OK. I wasn't looking for one. Six and a half years, and I still check in with the support group every day. I still read your comments on the blog every day. I still look around the net to see what's new for Follicular Lymphoma every day. Every day. And I still welcome new experiences, and ways to share the world with my family, and opportunities to live my life. Every day. Cancer is only one part of those days -- as small a part as I decide it's going to be.
It's good to be back.
My wife, kids, and I went to the United Kingdom for two weeks -- 5 days in London, 4 in Cornwall in Southwest England, and then 5 days up north in Edinburgh, Scotland. It was a great trip for all of us. My Doctor Who fan daughter got to see the TARDIS in Earls Court; my middle child, who has embraced his Scottish heritage, got to eat real haggis in Scotland; and my oldest, the jazz musician, got to see Bill Evans and Mike Stern, who played with Miles Davis in the 80's, in concert as part of the Edinburgh Jazz and Blues Festival.
It was the first visit to England for me and the kids, though my wife had been there before we were married. So this was also her way of keeping her promise to show me England some day. I still need to keep my promise to show her Italy, where I lived for 10 months years ago.
It was a great trip, and a much-needed one. We had a really tough spring. My shoulder surgery and recovery was only a part of it, and I won't get into the rest of it here. But it seemed like someone was just piling more and more tests on us as the spring went on. We passed those tests, and we're all better for it. And the trip to England and Scotland became, in some ways, a celebration of getting through the spring, a way of re-setting our lives and starting over, but also a way of remembering someone we love.
And while it seemed like I had been writing from the UK every few days, to be honest, I had actually written most of that stuff before I left, and posted it as I went along. That meant that I took a chance on writing a post about missing our dog, but it worked out OK, because we really did miss her. And she missed us, too. She didn't pass out when she saw us, like this other schnauzer did (in a video conveniently posted on YouTube yesterday), but she was happy to see us anyway.
It's funny, though, how it's almost impossible to take a vacation from cancer. It seemed like there was always a reminder. One museum we visited showed artifacts from vikings who had lived on the British Isles, including a quiver full of arrows -- anyone who has read this blog knows the specialist I saw long ago called the available lymphoma treatments the "arrows in your quiver." And it seemed like every major street in every town we visited had a few "charity shops," what we in the U.S. know as Goodwill or Salvation Army stores. And a whole bunch of those shops supported Cancer Research UK. And then outside Edinburgh Castle, a man dressed as William Wallace from Braveheart (as opposed to the real William Wallace) posed for pictures with tourists, accepting donations in a box, with a sign that said "All Donations to Support Leukemia Research."
I think we all probably knew already that there's no vacation from cancer. And that's OK. I wasn't looking for one. Six and a half years, and I still check in with the support group every day. I still read your comments on the blog every day. I still look around the net to see what's new for Follicular Lymphoma every day. Every day. And I still welcome new experiences, and ways to share the world with my family, and opportunities to live my life. Every day. Cancer is only one part of those days -- as small a part as I decide it's going to be.
It's good to be back.
Thursday, July 24, 2014
Idelalisib Approved for Follicular Lymphoma
The FDA announced yesterday that Idelalisib has been approved for treatment of three types of indolent NHL, including Follicular Lymphoma.
Also, it seems like the name is now being changed to Zydelig, to conform to the rule that all newly approved drugs have to have a Z or an X in their name, preferably both. Which stinks, because I finally learned how to spell Idelalisib without having to look it up every time.
This is excellent news. Idelalisib/Zydelig received Accelerated Approval for Follicular Lymphoma, for patients who have had at least two previous treatments. Accelerated Approval means that the approval was based on results of a phase 2 clinical trial, rather than a larger phase 3 trial (though the manufacturer will still need to conduct another trial to confirm the phase 2 results).The trial that resulted in the approval involved 123 patients with either FL or SLL (another indolent lymphoma) who were no longer being helped by Rituxan or traditional chemotherapy. The study found that 54% of Follicular Lymphoma patients responded to Idelalisib/Zydelig.
Idelalisib/Zydelig is an oral treatment, taken in pill form. It is a kinase inhibitor, targeting and stopping a protein that is responsible for cancer cells thriving and growing.
The FDA's announcement, however, makes very clear that there are some side effects associated with Idelalisib/Zydelig (there are always side effects). So while the treatment looks promising, it's still something that needs to be discussed seriously with an oncologist.
Two big take-aways from this, I think:
The first and most obvious is that we have another arrow in the quiver. Options are good, especially options that seem to work when Rituxan and chemo stop working.
The second is a little less direct, but just as important: the FDA is making serious attempts to get treatments to patients through "Breakthrough Status" and "Accelerated Approval" processes. Traditional approval for Idelalisib/Zydelig would have meant months or years of developing, recruiting, conducting, and reporting on a phase 3 study. I think the Accelerated Approval is as important as the approval itself. My guess is it won't be the last one we see in the next few years.
Also, it seems like the name is now being changed to Zydelig, to conform to the rule that all newly approved drugs have to have a Z or an X in their name, preferably both. Which stinks, because I finally learned how to spell Idelalisib without having to look it up every time.
This is excellent news. Idelalisib/Zydelig received Accelerated Approval for Follicular Lymphoma, for patients who have had at least two previous treatments. Accelerated Approval means that the approval was based on results of a phase 2 clinical trial, rather than a larger phase 3 trial (though the manufacturer will still need to conduct another trial to confirm the phase 2 results).The trial that resulted in the approval involved 123 patients with either FL or SLL (another indolent lymphoma) who were no longer being helped by Rituxan or traditional chemotherapy. The study found that 54% of Follicular Lymphoma patients responded to Idelalisib/Zydelig.
Idelalisib/Zydelig is an oral treatment, taken in pill form. It is a kinase inhibitor, targeting and stopping a protein that is responsible for cancer cells thriving and growing.
The FDA's announcement, however, makes very clear that there are some side effects associated with Idelalisib/Zydelig (there are always side effects). So while the treatment looks promising, it's still something that needs to be discussed seriously with an oncologist.
Two big take-aways from this, I think:
The first and most obvious is that we have another arrow in the quiver. Options are good, especially options that seem to work when Rituxan and chemo stop working.
The second is a little less direct, but just as important: the FDA is making serious attempts to get treatments to patients through "Breakthrough Status" and "Accelerated Approval" processes. Traditional approval for Idelalisib/Zydelig would have meant months or years of developing, recruiting, conducting, and reporting on a phase 3 study. I think the Accelerated Approval is as important as the approval itself. My guess is it won't be the last one we see in the next few years.
PI3K
delta, a protein that is over-expressed in many B-cell malignancies
and plays a role in the viability, proliferation and migration of
these
cancer cells - See more at:
http://www.gilead.com/news/press-releases/2014/7/us-food-and-drug-administration-approves-gileads-zydelig-idelalisib-for-relapsed-chronic-lymphocytic-leukemia-follicular-lymphoma-and-small-lymphocytic-lymphoma#sthash.VDHyLFWM.dpuf
PI3K
delta, a protein that is over-expressed in many B-cell malignancies
and plays a role in the viability, proliferation and migration of
these
cancer cells - See more at:
http://www.gilead.com/news/press-releases/2014/7/us-food-and-drug-administration-approves-gileads-zydelig-idelalisib-for-relapsed-chronic-lymphocytic-leukemia-follicular-lymphoma-and-small-lymphocytic-lymphoma#sthash.VDHyLFWM.dpuf
Tuesday, July 22, 2014
Zevalin Update for Follicular Lymphoma
From a couple of weeks ago, and early publication from The Annals of Hematology reporting on the long-term success of some Follicular Lymphoma patients who had received Zevalin.
A quick explanation if you don't know what Zevalin is:
Zevalin is a type of RadioImmuno Therapy, or RIT. Traditional radiation had limited use on most types of blood cancers, since radiation can't usually hit a moving target, like a circulating blood cell. RIT takes something that tracks down blood cells (think Rituxan) and attaches a small dose of radiation to it, so it can be delivered directly to the affected blood cells.
Zevalin, and other RITs, have had some success, but for a whole bunch of reasons, are not used very often on Follicular Lymphoma patients. Read more on RIT at Lymphomation.org.
So this study looked at 37 Follicular Lymphoma patients who had received Zevalin. As I said, Zevalin works: 34 of the 37 had a Complete Response. Long term, it did its job for most of the patients, though it certainly wasn't a cure. Patients reported decent Quality of Life results, too. I'll let you look at the numbers yourselves.
I think, even with a small study like this which is "outside of a clinical trial," it's clear that Zevalin is effective long-term. I'm not sure this adds anything new to what we've known about Zevalin, and since it's outside of a clinical trial, there are lots of questions about how representative the patients are.
But it's nice to see at least some evidence that Zevalin is still a valid option for us.
I'm not sure this study will result in increased use, but it keeps it at the front of everyone's minds, anyway, which might be about the best we can hope for. Good to remember that arrow is in the quiver.
A quick explanation if you don't know what Zevalin is:
Zevalin is a type of RadioImmuno Therapy, or RIT. Traditional radiation had limited use on most types of blood cancers, since radiation can't usually hit a moving target, like a circulating blood cell. RIT takes something that tracks down blood cells (think Rituxan) and attaches a small dose of radiation to it, so it can be delivered directly to the affected blood cells.
Zevalin, and other RITs, have had some success, but for a whole bunch of reasons, are not used very often on Follicular Lymphoma patients. Read more on RIT at Lymphomation.org.
So this study looked at 37 Follicular Lymphoma patients who had received Zevalin. As I said, Zevalin works: 34 of the 37 had a Complete Response. Long term, it did its job for most of the patients, though it certainly wasn't a cure. Patients reported decent Quality of Life results, too. I'll let you look at the numbers yourselves.
I think, even with a small study like this which is "outside of a clinical trial," it's clear that Zevalin is effective long-term. I'm not sure this adds anything new to what we've known about Zevalin, and since it's outside of a clinical trial, there are lots of questions about how representative the patients are.
But it's nice to see at least some evidence that Zevalin is still a valid option for us.
I'm not sure this study will result in increased use, but it keeps it at the front of everyone's minds, anyway, which might be about the best we can hope for. Good to remember that arrow is in the quiver.
Saturday, July 19, 2014
Stem Cell Transplants....For Dogs
As I mentioned a week or so ago, I've been away for a little while. Couldn't bring the dog. I miss her, even though she's useless to me as a cancer-sniffing dog. (Really, she's kind of useless as a dog in general. But she's sweet and she looks great, so we go with that. here's the little princess:
We assume she misses us, too.)
Anyway, I've been thinking about her, and it reminded me of an article from last month on dogs with lymphoma. I'd never wish lymphoma on any creature, two- or four-legged, but it's pretty cool to hear about how work on human lymphoma at the Fred Hutchinson Cancer Center in Seattle is being used to help dogs.
Also, there's some good news about cancer vaccines for dogs, too.
Obviously, dogs aren't people, but maybe the things we learn from dogs can be translated in some way to what we know about people cancer. Even indirectly.
I still miss my dog. We'll be home soon, baby. And I know you're in great hands, and probably having a much better time than you would with us, anyway. You'd just be sitting at my feet while I read cancer journals, rather than playing with your friends.
Hope everyone is staying healthy.
We assume she misses us, too.)
Anyway, I've been thinking about her, and it reminded me of an article from last month on dogs with lymphoma. I'd never wish lymphoma on any creature, two- or four-legged, but it's pretty cool to hear about how work on human lymphoma at the Fred Hutchinson Cancer Center in Seattle is being used to help dogs.
Also, there's some good news about cancer vaccines for dogs, too.
Obviously, dogs aren't people, but maybe the things we learn from dogs can be translated in some way to what we know about people cancer. Even indirectly.
I still miss my dog. We'll be home soon, baby. And I know you're in great hands, and probably having a much better time than you would with us, anyway. You'd just be sitting at my feet while I read cancer journals, rather than playing with your friends.
Hope everyone is staying healthy.
Tuesday, July 15, 2014
Bendamustine: An Overview
The July issue of the Leukemia and Lymphoma journal features an article written by Dr. Enrico Derenzini, Dr. Pier Luigi Zinzani, and Lymphoma Rock star Dr. Bruce Cheson, called "Bendamustine: Role and Evidence in Lymphoma Therapy, An Overview."
The article is written for oncologists who want to know more about Bendamustine and how it might be used for a number of lymphomas and other blood cancers, including Follicular Lymphoma, of course.
The article gives some history on how Bendamustine was developed, how and why it works on lymphoma cells, how it might best be used, and what clinical trials have told us about its effectiveness.
In the article, you'll learn some fascinating tidbits, like:
Anyway, the stuff that you actually learn from the article is pretty interesting on its own, particularly given how much more common Bendamustine is becoming as a treatment for Follicular Lymphoma. As I have mentioned before, Dr. R and I have talked about it as a possible next treatment for me, when it becomes necessary to have one, so I have a special interest in learning more about it.
The article gives some history on how Bendamustine was developed, how and why it works on lymphoma cells, how it might best be used, and what clinical trials have told us about its effectiveness.
In the article, you'll learn some fascinating tidbits, like:
- Bendamustine was developed in East Germany in the early 1960s, but wasn't widely used or known about in Western Europe and the U.S. until the early 1990s, after things opened up over there.
- It is related to the mustard has used in World War I.
- It is generally better tolerated and more effective than CHOP, especially when combined with Rituxan.
- It was named for Benedetto DaMustini, a young Italian immigrant who sold sausages from a small stand outside the East German hospital where it was developed. One night, after a long session of working on the compound, the lead researcher was about to give up on his efforts. He stopped for a sausage at the stand, and, refreshed by his snack, returned to work in the lab. A few hours later, he had his breakthrough. He went outside, thanked the boy for his sausage, asked the boy his name, and declared that he would name his new cancer treatment Bendamustine after young Benedetto DaMustini.
Anyway, the stuff that you actually learn from the article is pretty interesting on its own, particularly given how much more common Bendamustine is becoming as a treatment for Follicular Lymphoma. As I have mentioned before, Dr. R and I have talked about it as a possible next treatment for me, when it becomes necessary to have one, so I have a special interest in learning more about it.
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