tag:blogger.com,1999:blog-781671514856579833.post5296475321627553237..comments2024-03-27T08:59:24.243-04:00Comments on Lympho Bob: Narrowing Down Our Choices for Follicular Lymphoma Treatment?Lymphomaniachttp://www.blogger.com/profile/17519575154615844854noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-781671514856579833.post-13872494212879997032016-01-25T13:37:02.084-05:002016-01-25T13:37:02.084-05:00Thanks, BOb!Thanks, BOb!Rodrigohttps://www.blogger.com/profile/03752723170397341265noreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-9279301679762197972016-01-25T11:53:30.603-05:002016-01-25T11:53:30.603-05:00Ruben,
I agree -- it's going to take a while t...Ruben,<br />I agree -- it's going to take a while to measure OS, which is probably why they are using PFS instead.<br />I have no idea what will be added to make R + R even better. Researchers seem to understand that combinations seem to be effective, since the different treatments attack the cancer cells in different ways. Right now, there are trials that combine R + R with Bendamustine, with Ibrutinib, with Idelalisib....I'm guessing that anything that works will be combined with something else that works until we know which combinations work best.<br />Of course, that means we need more people willing to join clinical trials to test all of these combinations. Something for us all to consider....<br />BobLymphomaniachttps://www.blogger.com/profile/17519575154615844854noreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-81070611684627166712016-01-25T11:40:44.266-05:002016-01-25T11:40:44.266-05:00Rodrigo -- Just to be clear, PFS is typically meas...Rodrigo -- Just to be clear, PFS is typically measured at the beginning of the process, not the end. It might be at diagnosis (if the "treatment" is watching and waiting), or the day of the first treatment, or the day of enrollment in a clinical trial, but it won't be at the end of treatment. All of the days of treatment are included in that measurement. <br />PFS is kind of controversial as a measure of success for a treatment, though so are most measures, including Overall Survival. Lymphomation wrote up a thoughtful piece on PFS a few years ago in response to the PRIMA study on Rituxan Maintenance:<br />http://www.lymphomation.org/PFS-endpoint.pdf<br />Lymphomaniachttps://www.blogger.com/profile/17519575154615844854noreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-83562455734494967612016-01-25T10:50:36.698-05:002016-01-25T10:50:36.698-05:00Thanks for the reply. That makes total sense in or...Thanks for the reply. That makes total sense in order to have a baseline comparison. <br /><br />KevinAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-55932947377352900112016-01-25T07:42:10.925-05:002016-01-25T07:42:10.925-05:00It's going to take quite a number of years bef...It's going to take quite a number of years before that R+R group will reveal their median Overal survival rate. I must say, I am very pleased with that number. The big question is now, what can we add to that R+R regimen in order to attack the Lymphoma from all directions and kill it once and for all ;-) What's your best guess, Bob?<br /><br />Thanks for your work, looking forward to your next post!Rubennoreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-84486245383169923432016-01-24T19:41:01.619-05:002016-01-24T19:41:01.619-05:00Bob. When you said "first treatment ", i...Bob. When you said "first treatment ", it includes the rituximab maintenence (two years) or not?Rodrigohttps://www.blogger.com/profile/03752723170397341265noreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-91662433969756873432016-01-24T19:37:00.104-05:002016-01-24T19:37:00.104-05:00I have the same question: when we start counting T...I have the same question: when we start counting The PFS: after The diagnosys, after the complete remission, or the rituximab maintence (2 years) . This information is very important to understand these datasRodrigohttps://www.blogger.com/profile/03752723170397341265noreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-51154975572336425872016-01-24T19:26:38.777-05:002016-01-24T19:26:38.777-05:00Kevin, I believe that statistic is measured from t...Kevin, I believe that statistic is measured from the date of first treatment, so there is consistency when they make those comparisons. I don't see that information specifically in the article, but I have seen that explained somewhere else.<br />Good luck to you and your wife. I hope the maintenance goes smoothly.<br />Bob<br />Lymphomaniachttps://www.blogger.com/profile/17519575154615844854noreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-44645588440429211892016-01-24T18:27:24.288-05:002016-01-24T18:27:24.288-05:00I'm trying to understand the statistic. For th...I'm trying to understand the statistic. For the people receiving maintenance, does the 3 year PFS include the maintenance time? My wife completed 6 rounds of B + R at the end of March 2015. We are 7 months into a 2 year R-Maintenance period, which is one infusion every two months. We are due to end maintenance in June of 2017. So, does the study suggest that we have a 97% chance of 3 year PFS after maintenance, or is it from the end of the initial B + R treatment? The statistic makes it sound like that B + R + Maintenance consists of one treatment. By the way, I love the high percentages for the treatment my wife received and for the R squared. <br /><br />Thanks,<br /><br />KevinAnonymousnoreply@blogger.com