tag:blogger.com,1999:blog-781671514856579833.post1780240938024148626..comments2024-03-27T08:59:24.243-04:00Comments on Lympho Bob: ASH: Obinutuzumab (Two Studies)Lymphomaniachttp://www.blogger.com/profile/17519575154615844854noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-781671514856579833.post-18494249812941242482018-09-12T09:34:03.147-04:002018-09-12T09:34:03.147-04:00Obinutuzumab is a humanized monoclonal antibody th...Obinutuzumab is a humanized monoclonal antibody that inhibits CD20 for cancer therapy. In combination with chlorambucil, it was approved as a first-line treatment for chronic lymphocytic leukemia. It also can be used to treat follicular lymphoma. <a href="https://www.bocsci.com/obinutuzumab-cas-949142-50-2-item-7212.html" rel="nofollow">Obinutuzumab</a><br />Anonymoushttps://www.blogger.com/profile/12128271861530734257noreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-51725055103269348172016-11-15T19:46:31.554-05:002016-11-15T19:46:31.554-05:00Tom, this combination is approved as a first-line ...Tom, this combination is approved as a first-line treatment and a second-line treatment following Rituxan. I don't think it was approved specifically as an option for patients who can no longer take Rituxan, but it seems like a logical assumption that it would be worth trying on that population.<br />Lymphomaniachttps://www.blogger.com/profile/17519575154615844854noreply@blogger.comtag:blogger.com,1999:blog-781671514856579833.post-82227310434734158002016-11-12T01:53:22.439-05:002016-11-12T01:53:22.439-05:00Hi Bob
That sounds great. One question would also...Hi Bob<br /><br />That sounds great. One question would also be, how the cells reaction to Obinutuzumab would be, after patients got resistant to Rituximab ? In other words, does it still have a role in later line treatment, after Rituximab eventually stops working ? I ask because both are targeting the CD20, and the murine or human part might not be the issue in resisrance building process.<br />This study is only about induction, if I got it right ?<br />And thanks always for this great blog.<br />TomTom68https://www.blogger.com/profile/06801257416999076633noreply@blogger.com